An isolated 1,000-acre beef ranch in Tomasini Canyon north of Point Reyes Station may leave the hands of the ranching family that has owned it for over a century. Last week, owner Leroy Martinelli listed the property—minus a parcel that houses a defunct landfill—for $12.3 million. 

If it sells, the land could fall out of agricultural use. Mr. Martinelli said he attempted to sell development rights to the Marin Agricultural Land Trust but encountered legal…